Publications

Dr. Fedele’s research activity is mainly focused on clinical and translational research in Oral Medicine. To date, he has published over 70 papers in both general medical and specialist journals.

1. Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, Kelly JA, Dozmorov MG, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta M-L, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Jazebi H, Cunninghame Graham DS, Grandits ME, Nazmul-Hossain ANM, Patel K, Adler AJ, Maier-Moore JS, Farris AD, Brennan MT, Lessard JA, Chodosh J, Gopalakrishnan R, Hefner KS, Houston GD, Huang AJW, Hughes PJ, Lewis DM, Radfar L, Rohrer MD, Stone DU, Wren JD, Vyse TJ, Gaffney PM, James JA, Omdal R, Wahren-Herlenius M, Illei GG, Witte T, Jonsson R, Rischmueller M, Rönnblom L, Nordmark G, Ng WF for UK Primary Sjögren’s Syndrome Registry, Mariette X, Anaya J-M, Rhodus NL, Segal BM, Scofield RH, Montgomery CG, Harley JB and Sivils KL. Identification of multiple genetic variants associated with Sjögren’s syndrome involved in both the innate and adaptive immune responses. Nature Genetics 2013 Nov;45(11):1284-92.

2. Juarez M, Toms T, de Pablo P, Mitchell S, Bowman SJ, Nightingale P, Price E, Griffiths B, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, Pease C, Andrews J, Emery P, Regan M, Giles I, Isenberg D, Moots R, Collins K, Ng WF, Kitas GD on behalf of the UK primary Sjögren’s syndrome registry. Cardiovascular risk factors in females with Primary Sjögren’s syndrome: United Kingdom Primary Sjögren’s syndrome registry results. Arthritis Care Res. [accepted]

3. Lendrem D, Mitchell S, McMeekin P, Bowman S, Price E, Pease CT, Emery P, Andrews J, Lanyon P, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Vadivelu S, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Griffiths B, Ng WF; on behalf of the UK primary Sjögren’s Syndrome Registry. Health-related utility values of patients with primary Sjogren’s syndrome and its predictors. Ann Rheum Dis. 2013 Jun 12. [Epub ahead of print]

4. Fedele S, Fung PP, Bamashmous N, Petrie A, Porter S. Long-term effectiveness of intralesional triamcinolone acetonide therapy in orofacial granulomatosis: an observational cohort study. Br J Dermatol. 2013 Oct 1. doi: 10.1111/bjd.12655. [Epub ahead of print] PubMed PMID: 24088036.

5. Nordmark G, Wang C, Vasaitis L, Eriksson P, Theander E, Kvarnström M, Forsblad-d’Elia H, Jazebi H, Sjöwall C, Reksten TR, Brun JG, Jonsson MV, Johnsen SJ, Wahren-Herlenius M, Omdal R, Jonsson R, Bowman S, Ng WF, Eloranta ML, Syvänen AC; UK Primary Sjögren’s Syndrome Registry. Association of genes in the NF-κB pathway with antibody-positive primary Sjögren’s syndrome. Scand J Immunol. 2013 Nov;78(5):447-54.

6. Almouhawis HA, Leao JC, Fedele S, Porter SR. Wegener’s granulomatosis: a review of clinical features and an update in diagnosis and treatment. J Oral Pathol Med. 2013 Aug;42(7):507-16

7. Said AK, Leao JC, Fedele S, Porter SR. Focal epithelial hyperplasia – an update. J Oral Pathol Med. 2013 Jul;42(6):435-42.

8. Dastoori M, Fedele S, Leao JC, Porter SR. Sarcoidosis – a clinically orientated review. J Oral Pathol Med. 2013 Apr;42(4):281-9.

9. Collins K, Mitchell S, Griffiths B, Bowman SJ, Ng WF on behalf of the United Kingdom primary Sjögren’s syndrome registry. Potential diagnostic utility of anti-centromere antibody in primary Sjögren’s syndrome in the UK. Clin Rheumatol. 2012;31:1147-8. Epub 2012 May 31.

10. Newton JL, Frith J, Powell D, Hackett K, Wilton K, Bowman S, Price E, Pease C, Andrews J, Emery P, Hunter J, Gupta M, Vadivelu S, Giles I, Isenberg D, Lanyon P, Jones A, Regan M, Cooper A, Moots R, Sutcliffe N, Bombardieri M, Pitzalis C, McLaren J, Young-Min S, Dasgupta B, Griffiths B, Lendrem D, Mitchell S, Ng WF; on behalf of the UK primary Sjögren’s syndrome registry. Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren’s syndrome. Ann Rheum Dis. 2012 Dec;71(12):1973-9

11. Forster M, Mendes R, Fedele S. Synthetic lethality and PARP-inhibitors in oral and head & neck cancer. Curr Pharm Des. 2012;18(34):5431-41.

12. Diz P, Limeres J, Fedele S, Seoane J, Diniz M, Feijoo JF (2012). Is oral bisphosphonate-related osteonecrosis of the jaw an endemic condition? Med Hypotheses 78(2):315-8.

13. Nibali L, Fedele S, D’Aiuto F, Donos N (2012). Interleukin-6 in oral diseases: a review. Oral Dis. 18(3):236-43.

14. Fedele S, Sabbah W, Donos N, Porter S, D’Aiuto F (2011). Common oral mucosal diseases, systemic inflammation, and cardiovascular diseases in a large cross-sectional US survey. Am Heart J.161(2):344-50.

15. Fedele S, Porter SR, D’Aiuto F, Aljohani S, Vescovi P, Manfredi M, Arduino PG, Broccoletti R, Musciotto A, Di Fede O, Lazarovici TS, Campisi G, Yarom N. (2010) Nonexposed variant of bisphosphonate-associated osteonecrosis of the jaw: a case  series. Am J Med 123(11):1060-4.

16. Otto S, Abu-Id MH, Fedele S, Warnke PH, Becker ST, Kolk A, Mücke T, Mast G, Köhnke R, Volkmer E, Haasters F, Lieger O, Iizuka T, Porter S, Campisi G, Colella G, Ploder O, Neff A, Wiltfang J, Ehrenfeld M, Kreusch T, Wolff KD, Stürzenbaum SR, Schieker M, Pautke C. (2010) Osteoporosis and bisphosphonates-related  osteonecrosis  of the jaw: Not just a sporadic coincidence – a multi-centre study. J Craniomaxillofac Surg.

17. Porter SR, Fedele S, Habbab KM. (2010) Xerostomia in head and neck malignancy. Oral Oncol. 46(6):460-3.

18. Porter SR, Fedele S, Habbab KM. (2010) Taste dysfunction in head and neck malignancy. Oral Oncol 46(6):457-9

19. Gilvetti C, Porter SR, Fedele S (2010). Traumatic chemical oral ulceration: a case report and review of the literature. Br Dent J 208(7):297-300

20. Yarom,N, Fedele S, Elad, T.S., Sharon,L. (2010). Is exposure of the jawbone mandatory for establishing the diagnosis of bisphosphonate-related osteonecrosis of the jaw ? J Oral Maxillofacial Surg 68(3):705

21. Al Johani, K., Moles D.R., Porter, S.R., Fedele, S. (2010) Orofacial granulomatosis: clinical features and long-term outcome of therapy. J Am Acad Dermatol 62(4):611-20

22. Al Johani,K., Hegarty,A.M.,Porter,S.R.,Fedele S (2009) Calcineurin inhibitors in oral medicine. J Am Acad Dermatol 61(5):829-40

23. Mignogna MD, Fortuna G, Leuci S, Ruoppo E, Adamo D, Fedele S. (2009) Analysis of thromboembolic risk related to high-dose intravenous immunoglobulin treatment: a preliminary clinical study of 10 patients with autoimmune mucocutaneous blistering diseases. Clin Exp Dermatol. 34(2):145-50.

24. Al Johani, K., Moles,D.R., Hodgson,T., Porter,S.R., Fedele S (2009). Onset and progression of clinical manifestations of orofacial granulomatosis. Oral Dis. 2009 Apr ;15(3) :214-9.

25. Fedele, S., Kumar N, Davies R, Fiske J, Greening S, Porter S. (2009). Dental management of patients at risk of osteochemonecrosis of the jaws : a critical review. Oral Dis. 15(8):527-37

26. Fedele S (2009). Diagnostic aids in the screening of oral cancer. Head & Neck Oncology 1(5), 1-6. ISSN: 1758-3284

27. Porter,S.R., Al-Johani,K., Fedele S, Moles,D.R. (2009). Randomised controlled trial of the efficacy of HybenX in the symptomatic treatment of recurrent aphthous stomatitis. Oral Diseases 15(2), 155-161. ISSN: 1354-523X

28. Di Fede,O., Di Liberto,C., Occhipinti,G., Vigneri,S., Lo Russo,L., Fedele S, Lo Muzio,L., Campisi,G. (2008). Oral manifestations in patients with gastro-oesophageal reflux disease: a single-center case-control study. Journal of Oral Pathology and Medicine 37(6), 336-340. ISSN: 0904-2512

29. Fedele S, Lo Russo,L., Mignogna,C., Staibano,S., Porter,S.R., Mignogna,M.D. (2008). Macroscopic classification of superficial neoplastic lesions of the oral mucosa: a preliminary study. European Journal of Surgical Oncology 34(1), 100-106. ISSN: 0748-7983

30. Fedele S, Wolff,A., Strietzel,F.P., Granizo L¢pez,R.M., Porter,S.R., Konttinen,Y.T. (2008). An electro-stimulating oral splint for dry mouth treatment. Journal of the Israel Dental Association 25(4), 30-37. ISSN: 0792-9935

31. Fedele S, Wolff,A., Strietzel,F.,Lόpez,R.M.-G., Porter,S.R., Konttinen,Y.T. (2008). Neuroelectrostimulation in treatment of hyposalivation and xerostomia in Sjögren’s syndrome: a salivary pacemaker. Journal of Rheumatology 35(8), 1489-1494. ISSN: 0315-162X

32. Lo Russo,L., Fedele S, Guiglia,R., Ciavarella,D., Lo Muzio,L., Gallo,P., Di Liberto,C., Campisi,G. (2008). Diagnostic pathways and clinical significance of desquamative gingivitis. Journal of Periodontology 79(1), 4-24. ISSN: 0022-3492

33. Mignogna,M.D., Leuci,S., Fedele S, Ruoppo,E., Adamo,D., Russo,G., Pagliuca,R. (2008). Adjuvant high-dose intravenous immunoglobulin therapy can be easily treated and safely introduced as an alternative treatment in patients with severe pemphigus vulgaris: a retrospective preliminary study. American Journal of Clinical Dermatology 9(5), 323-331. ISSN: 1175-0561

34. Moles,D.R., Fedele S, Speight,P.M., Porter,S.R., Dos Santos Silva,I. (2008). Oral and pharyngeal cancer in South Asians and non-South Asians in relation to socioeconomic deprivation in South East England. British Journal of Cancer 98(3), 633-635. ISSN: 0007-0920

35. Al-Johani,K.A., Fedele S, Porter,S.R. (2007). Erythema multiforme and related disorders. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 103(5), 642-654. ISSN: 1079-2104

36. Fedele S, Fricchione,G., Porter,S.R., Mignogna,M.D. (2007). Burning mouth syndrome (stomatodynia) QJM 100(8), 527-530. ISSN: 1460-2725

37. Mignogna,M.D., Fedele S, Lo Russo,L., Mignogna,C., de Rosa,G., Porter,S.R. (2007). Field cancerization in oral lichen planus. European Journal of Surgical Oncology 33(3), 383-389. ISSN: 0748-7983

38. Mignogna,M.D., Fortuna,G., Ruoppo,E., Adamo,D., Leuci,S., Fedele S (2007). Variations in serum hemoglobin, albumin, and electrolytes in patients receiving intravenous immunoglobulin therapy: a real clinical threat? American Journal of Clinical Dermatology 8(5), 291-299. ISSN: 1175-0561

39. Moles,D.R., Fedele S, Speight,P.M., Porter,S.R. (2007). The unclear role of ethnicity in health inequalities: the scenario of oral cancer incidence and survival in the British south Asian population. Oral Oncology 43(8), 831-834. ISSN: 1368-8375

40. Strietzel,F.P., Martin-Granizo,R., Fedele S, Lo Russo,L., Mignogna,M.D., Reichart,P.A., Wolff,A. (2007). Electrostimulating device in the management of xerostomia. Oral Diseases 13(2), 206-213. ISSN: 1354-523X

41. Mignogna,M.D., Fedele S, Lo Russo,L. (2006). Dysplasia/neoplasia surveillance in oral lichen planus patients: a description of clinical criteria adopted at a single center and their impact on prognosis. Oral Oncology 42(8), 819-824. ISSN: 1368-8375

42. Mignogna,M.D., Lo Russo,L., Fedele S, Ciccarelli,R., Lo Muzio,L. (2006). Case 2. Osteonecrosis of the jaws associated with bisphosphonate therapy. Journal of Clinical Oncology 24(9), 1475-1477. ISSN: 0732-183X

43. Mignogna,M.D., Fedele S (2005). Oral cancer screening: 5 minutes to save a life. The Lancet 365(9475), 1095-1096. ISSN: 0140-6736

44. Mignogna,M.D., Fedele S, Lo Russo,L., Bonadies,G., Nappa,S., Lo Muzio,L. (2005). Acute cyclosporine nephrotoxicity in a patient with oral pemphigus vulgaris and HIV infection on antiretroviral therapy. Journal of the American Academy of Dermatology 53(6), 1089-1090. ISSN: 0190-9622

45. Mignogna,M.D., Fedele S, Lo Russo,L., Ciccarelli,R. (2005). Treatment of Gorham’s disease with zoledronic acid. Oral Oncology 41(7), 747-750. ISSN: 1368-8375

46. Mignogna,M.D., Fedele S, Lo Russo,L., Lanza,A., Marenzi,G., Sammartino,G. (2005). Gorham’s disease of the mandible mimicking periodontal disease on radiograph. Journal of Clinical Periodontology 32(9), 1022-1026. ISSN: 0303-6979

47. Mignogna,M.D., Fedele S, Lo Russo,L., Leuci,S., Lo Muzio,L. (2005). The diagnosis of burning mouth syndrome represents a challenge for clinicians. Journal of Orofacial Pain 19(2), 168-173. ISSN: 1064-6655

48. Mignogna,M.D., Fedele S, Lo Russo,L., Lo Muzio,L., Wolff,A. (2005). Sjögren’s syndrome: the diagnostic potential of early oral manifestations preceding hyposalivation/xerostomia. Journal of Oral Pathology and Medicine 34(1), 1-6. ISSN: 0904-2512

49. Mignogna,M.D., Lo Russo,L., Fedele S (2005). Gingival involvement of Oral Lichen Planus in a series of 700 patients. Journal of Clinical Periodontology 32(10), 1029-1033. ISSN: 0303-6979

50. Campisi,G., Fedele S, Lo Russo,L., Di Fede,O., Aricò,P., Craxì,A., Mignogna,M.D. (2004). HCV infection and oral lichen planus: a weak association when HCV is endemic. Journal of Viral Hepatitis 11(5), 465-470. ISSN: 1352-0504

51. Mignogna,M.D., Fedele S, Lo Russo,L., Adamo,D., Satriano,R.A. (2004). Effectiveness of small-volume, intralesional, delayed-release triamcinolone injections in orofacial granulomatosis: a pilot study. Journal of the American Academy of Dermatology 51(2), 265-268. ISSN: 0190-9622

52. Mignogna,M.D., Fedele S, Lo Russo,L. (2004). Anorexia/bulimia-related sialadenosis of palatal minor salivary glands. Journal of Oral Pathology and Medicine 33(7), 441-442. ISSN: 0904-2512

53. Mignogna,M.D., Fedele S, Lo Russo,L. (2004). The World Cancer Report and the burden of oral cancer. European Journal of Cancer Prevention 13(2), 139-142. ISSN: 0959-8278

54. Mignogna,M.D., Fedele S, Lo Russo,L., Lo Muzio,L., Bucci,E. (2004). Immune activation and chronic inflammation as the cause of malignancy in oral lichen planus: is there any evidence? Oral Oncology 40(2), 120-130. ISSN: 1368-8375

55. Mignogna,M.D., Fedele S, Lo Russo,L., Lo Muzio,L (2003). Sialorrhoea as early oral clinical manifestation of primary Sjögren’s syndrome? Rheumatology 42(9), 1113-1114. ISSN: 1462-0324

56. Mignogna,M.D., Fedele S, Lo Russo,L., Lo Muzio,L. (2003). The multiform and variable patterns of onset of orofacial granulomatosis. Journal of Oral Pathology and Medicine 32(4), 200-205. ISSN: 0904-2512

57. Mignogna,M.D., Lo Muzio,L., Ruoppo,E., Fedele S, Lo Russo,L., Bucci,E. (2002). High-dose intravenous ‘pulse’ methylprednisolone in the treatment of severe oropharyngeal pemphigus: a pilot study. Journal of Oral Pathology and Medicine 31(6), 339-344. ISSN: 0904-2512

58. Mignogna,M.D., Fedele S, Lo Russo,L., Ruoppo,E., Lo Muzio,L. (2002). Costs and effectiveness in the care of patients with oral and pharyngeal cancer: analysis of a paradox. European Journal of Cancer Prevention 11(3), 205-208. ISSN: 0959-8278

59. Mignogna,M.D., Fedele S, Lo Russo,L., Ruoppo,E., Lo Muzio,L. (2002). Polyglandular autoimmune syndrome type II associated with oral lichen planus. International Journal of Dermatology 41(4), 244-246. ISSN: 0011-9059

60. Mignogna,M.D., Fedele S, Ruoppo,E., Lo Russo,L. (2002). The role of molecular techniques in preventing oral cancer and improving its poor prognosis: an illusion? Journal of Oral Pathology and Medicine 31(4), 246-248. ISSN: 0904-2512

61. Mignogna,M., Fedele S, Lo Russo,L., Ruoppo,E., Adamo,D., Lo Muzio,L. (2002), Extrahepatic manifestations of Hepatitis C virus infection: the slowly unravelling picture of oral lichen planus. J Hepatol. Sep;37(3):412-3

62. Mignogna,M.D., Lo Russo,L., Fedele S, Ruoppo,E., Califano,L., Lo Muzio,L. (2002). Clinical behaviour of malignant transforming oral lichen planus. European Journal of Surgical Oncology 28(8), 838-843. ISSN: 0748-7983

63. Mignogna,M.D., Fedele S, Lo Russo,L., Lo Muzio,L. (2001). Orofacial granulomatosis with gingival onset. Journal of Clinical Periodontology 28(7), 692-696. ISSN: 0303-6979

64. Mignogna,M.D., Fedele S, Lo Russo,L., Ruoppo,E., Lo Muzio,L. (2001). A case of oral localized histoplasmosis in an immunocompetent patient. European Journal of Clinical Microbiology and Infectious Diseases 20(10), 753-755. ISSN: 0934-9723

65. Mignogna,M.D., Fedele S, Lo Russo,L., Ruoppo,E., Lo Muzio,L. (2001). Lack of public awareness toward alcohol consumption as risk factor for oral and pharyngeal cancers. Preventive Medicine 33(2), 137-139. ISSN: 0091-7435

66. Mignogna,M.D., Fedele S, Lo Russo,L., Ruoppo,E., Lo Muzio,L. (2001). Oral and pharyngeal cancer: lack of prevention and early detection by health care providers. European Journal of Cancer Prevention 10(4), 381-383. ISSN: 0959-8278

67. Mignogna,M.D., Fedele S, Lo Russo,L., Ruoppo,E., Lo Muzio,L. (2001). Unexpected low incidence of oral lichen planus in an HCV hyperendemic area of southern Italy. Gastroenterology 121(6), 1528-1529. ISSN: 0016-5085

68. Mignogna,M.D., Lo Muzio,L., Lo Russo,L., Fedele S, Ruoppo,E., Bucci,E. (2001). Metastases in small thickness squamous cell carcinoma arising in oral lichen planus. Medical Oncology 18(2), 169-173. ISSN: 1357-0560

69. Mignogna,M.D., Lo Russo,L., Fedele S, Ruoppo,E., Lo Muzio,L., Bucci,E. (2001). Clinical guidelines in early detection of OSCC arising in oral lichen planus: a five years experience. Oral Oncology 37(3), 262-267. ISSN: 1368-8375

70. Mignogna MD, Fedele S, Lo Russo L. (2000) International diagnostic criteria and delay of diagnosis in Behçet’s disease. J Rheumatol. 27(11):2725

71. Mignogna,M.D., Lo Muzio,L., Lo Russo,L., Fedele S, Ruoppo,E., Bucci,E. (2000). Oral lichen planus: different clinical features in HCV-positive and HCV-negative patients. International Journal of Dermatology 39(2), 134-139. ISSN: 0011-9059